panluminate develops the chemistry, instruments, and software that make synaptic-resolution brain mapping possible at scale. Our Signature Service puts that capability to work on your tissue today.
Trusted by leading research institutions
One workflow, from tissue to connectome. Each step has its own instrument, designed to work with the others. panluminate is the only company developing all three.
Tissue expansion, automated.
panexpanse runs pan-ExM sample preparation without an operator at the bench, so every sample expands and pan-stains the same way, batch after batch.
Running pan-ExM at your own bench? Our pan-ExM kits bring the same chemistry to your lab.
A light-sheet microscope built for expanded tissue.
panoptix images large expanded samples in near-isotropic 3D, with a sample chamber designed around pan-ExM. Jointly developed with 3i.
From image to connectome.
cortex is our AI-native platform for molecular connectomics. It brings imaging data, dense segmentation, synapse detection, and molecular labels together so you can explore circuits and the molecules within them.
Dense segmentation model co-developed with Scalable Minds. Powered by WEBKNOSSOS.
pan-Expansion Microscopy (pan-ExM) physically enlarges tissue about 20-fold and stains all of its protein. A light microscope can then resolve individual synapses and up to eight molecular targets in the same sample.
Labeled proteins appear as isolated points, with no structure around them.
Every synapse, membrane, and organelle becomes visible, with detail approaching electron microscopy.
Specific proteins located precisely within their structural surroundings.
AI reconstructs neurons in 3D from pan-stained volumes, using molecular signals to pinpoint their synapses.
Segmentation powered by WEBKNOSSOS, co-developed with Scalable Minds.
Send us your tissue. The scientists who invented pan-ExM take it from study design through imaging data delivery, for academic labs, core facilities, pharmaceutical teams, and NeuroAI companies.
Our team has already expanded and imaged every one of these. More includes olfactory tissue, testes, and human postmortem tissue.
Synaptic-resolution imaging with molecular labeling, without building the method in-house.
Founding Core ProgramSee how disease models and treatments change synapses, and the molecules within them, in the same tissue.
Ground-truth data on how real neurons connect, and what they're made of.
NeuroAI Partner ProgramM'Saad O, Cairns A, Gulcicek J, et al.
Schueder F, Rivera-Molina F, Su M, Marin Z, Kidd P, Rothman JE, Toomre D, Bewersdorf J.
Tell us about your tissue and your research question. We'll respond within two business days.