Science
The science behind the platform.
Peer-reviewed research from the team that invented pan-Expansion Microscopy, and the methods every panluminate product is built on.
Publications
Peer-reviewed papers
- 2026npj ImagingRead ↗
pan-ASLM: Axially Swept Light Sheet Microscopy for Fast and High-Resolution Imaging of Expanded Samples
The light-sheet design behind panoptix.
- 2025Nature BiotechnologyRead ↗
All-optical visualization of specific molecules in the ultrastructural context of brain tissueFlagship
M'Saad O, Cairns A, Gulcicek J, et al.
The flagship pan-ExM paper for brain tissue.
- 2024CellRead ↗
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging
Schueder F, Rivera-Molina F, Su M, Marin Z, Kidd P, Rothman JE, Toomre D, Bewersdorf J.
- 2023ScienceRead ↗
Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin
Pownall ME, Miao L, Vejnar CE, M'Saad O, Sherrard A, Frederick MA, Benitez MDJ, Boswell CW, Zaret KS, Bewersdorf J, Giraldez AJ.
- 2020Nature CommunicationsRead ↗
Light microscopy of proteins in their ultrastructural context
M'Saad O, Bewersdorf J.
The original pan-ExM method.
Preprints and posters
Work in progress
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2026
Conference poster
Toward Scalable Molecular Connectomics Using pan-Expansion Microscopy
AI-assisted synapse mapping (pre-synapse F1 0.94, post-synapse F1 0.93), 8-plex co-registration, and 3D amyloid reconstruction.
See pan-ExM across brain, kidney, and epithelial tissue in the gallery.